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ZEG Berlin GmbH

Zentrum für Epidemiologie und Gesundheitsforschung

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The Aging Male Symptoms (AMS) Scale

Men and women develop similar complaints while aging

The AMS was developed in response to the lack of standardized scales to measure the severity of aging symptoms in men and their impact on quality of life.  Many men experience age-related symptoms similar to those traditionally ascribed to women.  Experiences include impaired memory, lack of concentration, nervousness, depression, insomnia, periodic sweating or hot flushes, bone & joint complaints, and reduction of muscle mass. Despite Werner 1 reporting the similarity of male and female complaints as early as the 1940s, age-related complaints in men have only recently been seen in the context of hormonal involution. The debate about male climacteric, as well as its compatibility with female menopause, continues. 234

Sensations of sweating occurring suddenly and unexpectedly, particularly at night (hot flushes), seem common in men and women. The AMS is based on the hypothesis that sweating episodes might be an important symptom of the changes occurring during aging for both sexes. Moreover, developing a diagnostic instrument that assesses health-related changes in quality of life (HRQoL) in men may be beneficial for discussing potential treatment modalities.

Idenfification of Relevant Items

Key objectives

  • To measure health-related quality of life (QoL) or severity of complaints in aging males
  • To measure changes over time and across different cultures (AMS scale available in 29 languages)
  • To measure changes before/ after treatment of androgen deficiency
  • To measure in a standardized way

1. Werner AA. The male climacteric: report of 273 cases. JAMA 1946; 132:188-94.

2. Bauer J. The male climacteric – a misnomer. JAMA 1944; 126: 914-18.

3. Degenhardt A. Wechseljahre beim Mann, gibt es sie? In: Fischer S, Streb-Lieder & Vogt, eds. Wechseljahre für Fortgeschrittene. Frankfurt: Verlag für akademische Schriften. 1995: 104-18.

4. McKinlay JB, Longscope CH, Gray A. The questionable phys. and epidemiologic basis for a male climac-teric syndrome: preliminary results from the Massachusetts Male Aging Study. Maturitas 1989; 11:103-5.

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Berlin Center for Epidemiology and Health Research

Invalidenstraße 115
10115 Berlin
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Expertise

  • Real-World Evidence
  • Non-interventional study design
  • Post-authorization safety studies
  • Post-authorization efficacy studies
  • Cohort studies
  • Case-control studies
  • Medical Devices
  • Patient Reported Outcomes (PROs)
  • Data collection instruments

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We are a partner centre of the ENCePP scientific network which is coordinated by the European Medicines Agency. We are dedicated to excellence in research by adhering to the ENCePP Guide on Methodological Standards and promoting scientific independence and transparency. We register studies in the ENCePP E-Register of Studies, a publicly accessible resource for the registration of pharmacoepidemiological and pharmacovigilance studies.

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With a view to the introduction of the GDPR/EUDSGVO we are glad to present our newupdated privacy policy . The updated description are stored under “about us” and then “privacy policy/GDPR”. Further translation for study participants will follow contemporary.

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